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1)2018年8月,恭喜曾小东同学发表Adv.Healthc. Mater.2018, 1800589,1),http://www.materialsviewschina.com/2018/08/29848/

2)2018年5月,恭喜杨靖和周晖发表J. Proteome Res.论文,孙耀发表OBC论文

3)2018年1月,恭喜孙耀和曾小东的文章发表在Chem. Sci.上, 祝贺!!!

4)2017年5月,恭喜陈浩共第一的文章发表在Nat.Commun.上,祝贺!!!

5)2017年4月10日, 恭喜瞿春容,丁明敏共第一的文章发表在J. Med. Chem.上,并选为封面,祝贺!

6)2017.2.27恭喜孙耀、丁明敏、曾小东瞿共第一的文章文章发表在Chemical Science上, 祝贺!!!





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1

201010月起任武汉大学药学院教授,20114月任湖北省楚天学者特聘教授、武汉大学珞珈学者特聘教授,2018年月1月起西藏大学医学院教授(援藏)。病毒学国家重点实验室成员,组合生物合成与新药发现教育部重点实验室成员和发育源性疾病湖北省重点实验室成员。是中国生物物理学会分子影像学专业委员会委员,中国生物化学与分子生物学会蛋白质组学专业委员会理事,湖北省中小企业共性技术药物及药用材料研发推广中心主任,湖北省有机氟工程中心副主任,湖北省科技进步促进会常务理事,湖北省保健食品和化妆品评审员,湖北省药事管理专业委员会委员,武汉市药学会常务理事,《中国药物化学杂志》,《医药导报》和《武汉大学学报自然科学英文版》编委,Chinese Chemical Letters 青年编委。

2003年至今已在国内、国际核心化学期刊上发表相关论文包括Nat.Mater., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Inter. Ed., Chem. Sci. J. Med. Chem. Mol. Pharm., Proteomics, Org. Lett.J. Org. Chem.,ESI高被引和热点1篇,专利9个,完成英文专著两章承担国家自然科学基金面上基金等。2014年世界华人药学会最佳报告奖(美国化学学会颁),2015年度医学突出贡献奖、2016年度医学突出贡献奖和2016年朱裕璧医学奖。



代表论文著作Papers

1.       Y. Sun, X. Zeng, Y. Xiao, C. Liu, H.Zhu, H. Zhou, Z. Chen, F. Xu, J. Wang, M. Zhu, J. Wu, M. Tian, H. Zhang, Z.Deng, Z. Cheng*, X. Hong*, Dual-function near-infrared II fluorescenceand PET probe for tumor delineation and image-guided surgery. Chem. Sci.2018, 9, 2092-2097.

2.X. Zeng, Y.  Xiao, J. Lin, S.Li, H. Zhou, J. Nong, G. Xu, H. Wang, F. Xu, J. Wu, Z.Deng, X. Hong*, Near-Infrared II dye-proteincomplex for biomedical imaging and imaging-guided photothermal therapy. Adv.Healthc. Mater. 2018, 1800589.

3.M.Ding, H. Wang, C. Qu, F. Xu, Y.Zhu, G. Lv, Y. Lu, Q. Zhou, H. Zhou, X. Zeng, J.Zhang, C. Yan, J. Lin, H. Luo, Z. Deng, Y. Xiao, J.Tian, M. Zhu, X. Hong*,Pyrazole[1,5-a]pyrimidineTRPC6 antagonists for the treatment of gastric cancer, Cancer Lett. 2018, 432, 47–55.

4.       J. Yang, Q. Xie, H. Zhou, L.Chang, W. Wei, Y. Wang, H.Li, Z. Deng, Y. Xiao, J. Wu, P. Xu*, X. Hong*, J. Proteome Res.2018.10.1021/acs.jproteome.8b00181.

5.       Y. Sun, Z. Lyu, Z. Wang, X. Zeng, H. Zhou, F. Xu, Z. Chen, Y. Xu, P. Xu*X. Hong*, Facile Cu(II)-mediated conjugation of thioesters and thioacids topeptides and proteins under mild conditions. Org. Biomol. Chem., 2018,DOI: 10.1039/c8ob00536b.

6.       A. L. Antaris,†, H. Chen†, S. Diao, Z. Ma, Z. Zhang, S. Zhu, J. Wang, A.Lozano, Q. Fan, L. Chew, M. Zhu, K. Cheng, X. Hong*, H. Dai*, Z. Cheng*,A high quantum yield molecule-protein complex fluorophore fornear-infrared IIimaging. Nat. Commun. 20178,15269.

7.       C. Qu†, M. Ding†, Y. Zhu†, Y. Lu, J. Du, M. R. Miller,J.Tian, J. Zhu, J.Xu, M. Wen, AGA Er-Bu, J. Wang, Y. Xiao, M. Wu, O. B. McManus, M. Li, J. Wu, H.Luo, Z. Cao, B. Shen, H. Wang*, M. X. Zhu*, X. Hong*Pyrazolopyrimidines as potent stimulators fortransient receptor potential canonical 3/6/7 channels. J. Med. Chem., 2017,60 (11),4680−4692 (Cover Paper)

8.       Y. Sun, M. Ding, X. Zeng, Y. Xiao,H. Wu, H. Zhou, B. Ding, C. Qu, W. Hou, AGA Er-Bu, Y. Zhang, Z. Cheng , X.Hong* Chem. Sci. 2017, 8,3489-3493.

9.       A. Antaris, H. Chen, K. Cheng, Y. Sun, G. Hong, C. Qu, S. Diao, Z. Deng,X. Hu, B. Zhang, X. Zhang, O. K. Yaghi, Z. Alamparambil, X. Hong*, Z.Cheng*,H. Dai*. A small molecule dye for NIR II imaging. Nat. Mater., 2016,15(2), 235–242. (封面Highlight, ESI高被引和热点).

10.    Y. Sun, C. Qu, H. Chen, M. He, C.Tang, K. Shou, S.Hong, M. Yang, Y. Jiang, B. Ding, Y. Xiao, L. Xing, X. Hong*, Z. Cheng*Novel benzo-bis(1,2,5-thiadiazole)fluorophores for invivo NIR-II imaging of cancer,Chem. Sci., 2016, 7, 6203-6207.

11.    Y. Sun, S. Hong, X. Ma, K. Cheng, J. Wang, Z. Zhang, M. Yang, Y. Jiang, X.Hong*, Z. Cheng*.  Recyclable Cu(I)/Melanin dots forcycloadditions, bioconjugation and cell labeling. Chem. Sci., 2016,7, 5888-5892.

12.    Y. Sun†, X. Ma†, Z. Zhang, Z. Sun, M. Loft, B. Ding, C. Liu, L. Xu, M.Yang, Y. Jiang, J. Liu, Y. Xiao, Z. Cheng*, Xuechuan Hong*, Apreclinical study on GRPR-targeted 68Ga probes for PET imaging of prostatecancer. Bioconjugate Chem. 2016, 27(8),1857–1864.

13.    Y. Sun, X. Ma, K. Cheng, B. Wu, J. Duan, H. Chen, L. Bu, R. Zhang, X. Hu,Z. Deng, L. Xing, X. Hong*, Z. Cheng*. Strained cycloalkyne as a novelimaging platform for construction of the multivalent and dual-modaluPAR-targeted imaging probes. Angew. Chem. Int. Ed. 2015, 54(20),5981-5984. (HOT PAPER).

14.    Y. Zhu, Y. Lu, C. Qu, M. Miller, J. Tian, J. Zhu, Z. Deng, X. Hu, M. Wu,O. McManus, M. Li, X. Hong*, M. X. Zhu*, H. Luo*,Identification andoptimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4and TRPC5 channels.Brit. J. Pharmacol.2015, 172(14), 3495-3509.

15.    J. Lou, X. Yang, Z. Rao, W. Qi, J. Li, H. Wang, Y. Li, J. Li, Z. Wang, Xi.Hu, P. Liu*, X. Hong*. Design and synthesis of6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidaseinhibitors. Eur. J. Med. Chem., 2014, 83, 466-473.

16.    J. Li, J. Lou, Z. Wang, T. Wang, Y. Xiao, P. Liu, X. Hu, X. Hong*.Design, synthesis and pharmacological evaluation of novel N-(2-(1,1-dimethyl-5,7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives aspotential anticonvulsant agents. Eur. J. Med. Chem., 2015, 92,370-376.

17.    J. Duan, Y. Sun, H. Chen, G. Qiu, H. Zhou, T. Tang, Z. Deng, X. Hong*.Modification of peptides and proteins via HMDO-mediated ligation inionic liquids. J. Org. Chem. 2013, 78(14), 7013–7022.

18.    H. Liu, S. Liu, Z. Miao, H. Jiang, Z. Deng, X. Hong*, Z. Cheng*. Anovel aliphatic18F-labeled probe for PET imaging of Melanoma. Mol. Pharm.,2013,10(9), 3384-3391.

19.    L. Zhai, C. Chang, N. Li, D. M. Duong, H. Chen, Z.  Deng, J. Yang, X.Hong*, Y. Zhu, P.  Xu*. Systematic research of the pre-treatment ofpeptides for quantitative proteomics using the C18 micro-column, 2013, Proteomics,13(5), 2229–2237.

20.    J. Zhu, C. Wu, X. Li, G. Wu, S. Xie, Q. Hu, Z. Deng, M. X. Zhu, *H. Luo,* X.Hong*. Synthesis, biological evaluation and molecular modeling ofsubstituted2-aminobenzimidazoles as new dual inhibitors of acetylchlinesteraseand butyrylcholinesterase. Bioorg. Med. Chem., 2013,21,4218.

21.    H. Chen, M. He, Y. Wang, L. Zhai, Y. Cui, Y. Li, Yan Li, H. Zhou*, X.Hong*, ZixinDeng. Metal-free direct amidation of peptidyl thiol esters withamino acid esters. Green Chem., 2011, 13, 2723.

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