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1)2018年11月29日,恭喜林嘉诚和曾小东同学发表 Chemical Science论文,http://dx.doi.org/10.1039/C8SC04363A。

2) 2018年8月,恭喜曾小东同学发表Adv.Healthc. Mater.2018, 1800589,1),http://www.materialsviewschina.com/2018/08/29848/

3)2018年5月,恭喜杨靖和周晖发表J. Proteome Res.论文,孙耀发表OBC论文

4)2018年1月,恭喜孙耀和曾小东的文章发表在Chem. Sci.上, 祝贺!!!

5)2017年5月,恭喜陈浩共第一的文章发表在Nat.Commun.上,祝贺!!!

6)2017年4月10日, 恭喜瞿春容,丁明敏共第一的文章发表在J. Med. Chem.上,并选为封面,祝贺!

7)2017.2.27恭喜孙耀、丁明敏、曾小东瞿共第一的文章文章发表在Chemical Science上, 祝贺!!!





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1

201010月起任武汉大学药学院教授,湖北省楚天学者特聘教授、武汉大学珞珈学者特聘教授,2017年月12月起西藏大学医学院教授(援藏)。病毒学国家重点实验室成员,组合生物合成与新药发现教育部重点实验室成员和发育源性疾病湖北省重点实验室成员。是中国药理学会分析药理学专业委员会委员,中国生物物理学会分子影像学专业委员会委员,中国生物化学与分子生物学会蛋白质组学专业委员会理事,湖北省中小企业共性技术药物及药用材料研发推广中心主任,湖北省有机氟工程中心副主任,湖北省科技进步促进会常务理事,湖北省保健食品和化妆品评审员,湖北省药事管理专业委员会委员,《中国药物化学杂志》,《医药导报》和《武汉大学学报自然科学英文版》编委,Chinese Chemical Letters 青年编委。

2003年至今已在国内、国际核心化学期刊上发表相关论文包括Nat.Mater., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Inter. Ed., Chem. Sci. J. Med. Chem. Mol. Pharm., Proteomics, Org. Lett.J. Org. Chem.,ESI高被引1篇,专利9个,完成英文专著两章承担国家自然科学基金面上基金等。2014年世界华人药学会最佳报告奖(美国化学学会颁),2015年度医学突出贡献奖、2016年度医学突出贡献奖和2016年朱裕璧医学奖。



代表论文著作Papers

1.  J. Lin†, X. Zeng†, Y. Xiao†, L.Tang, J. Nong, Y. Liu, H.Zhou, B. Ding, F. Xu, H. Tong, . Deng, X. Hong*, Novel near-Infrared II aggregation-induced emission dots for in vivo bioimaging. Chem. Sci., 2018, DOI: 10.1039/C8SC04363A.

2.  Y. Sun†, X.Zeng†, Y. Xiao†, C. Liu, H.Zhu, H. Zhou, Z. Chen, F. Xu, J. Wang, M. Zhu, J.Wu, M. Tian, H. Zhang, Z. Deng, Z. Cheng*, X. Hong*, Dual-function near-infrared II fluorescence and PET probefor tumor delineation and image-guided surgery. Chem. Sci., 2018, 9,2092-2097.

3. X. Zeng†, Y. Xiao†, J. Lin, S. Li, H. Zhou, J. Nong, G. Xu, H. Wang, F. Xu, J. Wu, Z. Deng, X. Hong*, Near-Infrared IIdye-proteincomplex for biomedical imaging and imaging-guided photothermaltherapy. Adv. Healthc. Mater., 2018, 1800589.

4. M. Ding†, H.Wang†, C. Qu†, F. Xu†, Y. Zhu, G. Lv, Y. Lu, Q. Zhou, H. Zhou, X. Zeng, J. Zhang,C. Yan, J. Lin, H. Luo, Z. Deng, Y. Xiao, J. Tian, M. Zhu, X. Hong*, Pyrazole[1,5-a]pyrimidineTRPC6antagonists for the treatment of gastric cancer, Cancer Lett., 2018, 432,47–55.

5. J. Yang, Q.Xie, H. Zhou, L. Chang, W. Wei, Y. Wang, H. Li, Z. Deng, Y. Xiao, J. Wu, P.Xu*, X. Hong*, J. Proteome Res., 2018, 17, 24282439.

6. Y. Sun, Z.Lyu, Z. Wang, X. Zeng, H. Zhou, F. Xu, Z. Chen, Y. Xu, P. Xu*X.Hong*, Facile Cu(II)-mediatedconjugation of thioesters and thioacids topeptides and proteins under mildconditions. Org. Biomol. Chem., 2018,16, 3610–3614.

7. A. L.Antaris,†, H. Chen†, S. Diao, Z. Ma, Z. Zhang, S. Zhu, J. Wang, A. Lozano, Q.Fan, L. Chew, M. Zhu, K. Cheng, X.Hong*, H. Dai*, Z. Cheng*,A high quantum yield molecule-protein complexfluorophore for near-infrared II imaging. Nat. Commun., 2017, 8,15269.

8. C. Qu†, M.Ding†, Y. Zhu†, Y. Lu, J. Du, M. R. Miller, J. Tian, J. Zhu, J. Xu, M. Wen, AGAEr-Bu, J. Wang, Y. Xiao, M. Wu, O. B. McManus, M. Li, J. Wu, H. Luo, Z. Cao, B.Shen, H. Wang*, M. X. Zhu*, X. Hong*Pyrazolopyrimidines as potent stimulatorsfortransient receptor potential canonical 3/6/7 channels. J. Med. Chem., 2017,60 (11),46804692 (CoverPaper)

9. Y. Sun†, M.Ding†, X. Zeng†, Y. Xiao†,H. Wu, H. Zhou, B. Ding, C. Qu, W. Hou, AGA Er-Bu, Y.Zhang, Z. Cheng , X.Hong* ,Chem. Sci., 2017, 8,3489-3493.

10. A. Antaris,H. Chen, K. Cheng, Y. Sun, G. Hong, C. Qu, S. Diao, Z. Deng,X. Hu, B. Zhang, X.Zhang, O. K. Yaghi, Z. Alamparambil, X.Hong*, Z.Cheng*,H. Dai*. A small molecule dye for NIR II imaging. Nat. Mater., 2016, 15(2), 235–242. (封面Highlight,ESI高被引).

11. Y. Sun†, C.Qu†, H. Chen, M. He, C. Tang, K. Shou, S. Hong, M. Yang, Y. Jiang, B. Ding, Y.Xiao, L. Xing, X. Hong*, Z.Cheng*Novel benzo-bis(1,2,5-thiadiazole)fluorophoresfor in vivo NIR-II imaging of cancer, Chem. Sci., 2016, 7,6203-6207.

12. Y. Sun, S.Hong, X. Ma, K. Cheng, J. Wang, Z. Zhang, M. Yang, Y. Jiang, X.Hong*, Z. Cheng*.  RecyclableCu(I)/Melanin dots forcycloadditions, bioconjugation and cell labeling. Chem. Sci., 2016, 7, 5888-5892.

13. Y. Sun†, X.Ma†, Z. Zhang, Z. Sun, M. Loft, B. Ding, C. Liu, L. Xu, M.Yang, Y. Jiang, J.Liu, Y. Xiao, Z. Cheng*, X. Hong*, A preclinical study on GRPR targeted 68Ga probes for PET imaging of prostate cancer. Bioconjugate Chem., 2016, 27(8), 1857–1864.

14. Y. Sun, X.Ma, K. Cheng, B. Wu, J. Duan, H. Chen, L. Bu, R. Zhang, X. Hu,Z. Deng, L. Xing, X. Hong*, Z. Cheng*. Strainedcycloalkyne as a novel imaging platform for construction of the multivalent anddual-modal uPAR-targeted imaging probes. Angew. Chem. Int. Ed., 2015,54(20), 5981-5984. (HOT PAPER).

15. Y. Zhu, Y.Lu, C. Qu, M. Miller, J. Tian, J. Zhu, Z. Deng, X. Hu, M. Wu,O. McManus, M.Li, X. Hong*, M. X. Zhu*, H.Luo*,Identification andoptimization of 2-aminobenzimidazole derivatives asnovel inhibitors of TRPC4and TRPC5 channels. Brit. J. Pharmacol.2015,172(14), 3495-3509.

16. J. Li, J.Lou, Z. Wang, T. Wang, Y. Xiao, P. Liu, X. Hu, X. Hong*.Design, synthesis and pharmacological evaluation of novelN-(2-(1,1-dimethyl-5,7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamidederivatives as potential anticonvulsant agents. Eur. J. Med. Chem., 2015,92,370-376.

17. J. Lou, X.Yang, Z. Rao, W. Qi, J. Li, H. Wang, Y. Li, J. Li, Z. Wang, Xi.Hu, P.Liu*, X. Hong*. Design andsynthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives asneuraminidase inhibitors. Eur. J.Med. Chem., 2014, 83, 466-473.


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