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1)2017年4月10日, 恭喜瞿春容,丁明敏共第一的文章发表在J. Med. Chem.上,祝贺!

2) 2017.2.27恭喜孙耀、丁明敏、曾小东瞿共第一的文章文章发表在Chemical Science上, 祝贺!!!

3)热烈祝贺陈浩同学荣获2016年武汉大学研究生学术创新一等奖!!!

4)2016. 8.5 恭喜孙耀博士发表在BioconjugateChem.上,祝贺!!!

5)恭喜孙耀、瞿春容共第一的文章文章发表在Chemical Science上, 祝贺!!!

6)祝贺孙耀 博士发表Chem Sci.文章 

7)热烈祝贺陈浩同学发表Nature Materials文章!!!

8)热烈祝贺孙耀同学荣获2015年武汉大学研究生学术创新一等奖!!!






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1

201010月起任武汉大学药学院教授,20114月任湖北省楚天学者特聘教授。病毒学国家重点实验室成员,组合生物合成与新药发现教育部重点实验室成员和发育源性疾病湖北省重点实验室成员。是中国生物物理学会分子影像学专业委员会委员,中国生物化学与分子生物学会蛋白质组学专业委员会,湖北省中小企业共性技术药物及药用材料研发推广中心主任,湖北省有机氟工程中心副主任,湖北省科技进步促进会常务理事,湖北省保健食品和化妆品评审员,湖北省药事管理专业委员会委员,武汉市药学会常务理事,《医药导报》和《武汉大学学报自然科学英文版》编委。

2003年至今已在国内、国际核心化学期刊上发表相关论文包括Nat.Mater., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Inter. Ed., Chem. Sci. J. Med. Chem. Mol. Pharm., Proteomics, Org. Lett.J. Org. Chem.,ESI高被引1篇,专利9个,完成英文专著两章承担国家自然科学基金面上基金等。2014年世界华人药学会最佳报告奖(美国化学学会颁),2015年度医学突出贡献奖、2016年度医学突出贡献奖和2016年朱裕璧医学奖。



代表论文著作Papers


  1. AlexanderL. Antaris,†, Hao Chen†, Shuo Diao, Zhuoran Ma, Zhe Zhang, Shoujun Zhu, JoyWang, Alexander Lozano, Quli Fan, Leila Chew, Mark Zhu, Kai Cheng, Xuechuan Hong*, Hongjie Dai*, ZhenCheng*, A high quantum yield molecule-protein complex fluorophore fornear-infrared II imaging. Nat. Commun.2017NCOMMS-16-24795B,刚接收

  2. ChunrongQu†, Mingmin Ding†, Yingmin Zhu†, Yungang Lu, Juan Du, Melissa R. Miller,Jinbin Tian, Jinmei Zhu, Jian Xu, Meng Wen, AGA Er-Bu, Jule Wang, Yuling Xiao, Meng Wu, Owen B. McManus, Min Li, Jilin Wu, Huai-Rong Luo, Zheng-Yu Cao, Bing Shen,  Hongbo Wang*, Michael X. Zhu*, Xuechuan Hong*Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels. J. Med. Chem., 2017, Just Accepted Manuscript. DOI: 10.1021/acs.jmedchem.7b00304.

  3. Yao Sun, Mingmin Ding,Xiaodong Zeng, Yuling Xiao, Huaping Wu, Hui Zhou, Bingbing Ding, Chunrong Qu, Wei Hou, AGA Er-Bu, Yejun Zhang, Zhen Cheng , Xuechuan Hong* Chem. Sci. 2017, DOI: 10.1039/C7SC00251C.

  4. Alexander Antaris, Hao Chen, Kai Cheng, Yao Sun, Guosong Hong, Chunrong Qu, Shuo Diao, Zixin Deng, Xianming Hu, Bo Zhang, Xiaodong Zhang,  Omar K. Yaghi, Zita Alamparambil, Xuechuan Hong*, Zhen Cheng*,  Hongjie Dai*. A Small Molecule Dye for NIR II Imaging. Nature Materials, 2016, 15(2), 235–242. (封面Highlight, ESI高被引).

  5. Yao Sun,Chunrong Qu, Hao Chen, Maomao He, Chu Tang, Kangquan Shou, Su Hong, Meng Yang, Yuxing Jiang, Bingbing Ding, YulingXiao, Lei Xing, Xuechuan Hong* and Zhen Cheng*,Novel benzo-bis(1,2,5-thiadiazole) fluorophores for invivo NIR-II imaging of cancer, Chem. Sci., 2016, 7, 6203-6207.

  6. Yao Sun,  Su Hong, Xiaowei Ma,  Kai Cheng,  Jing     Wang , Zhe Zhang, Meng Yang,Yuxing Jiang, Xuechuan Hong*, Zhen Cheng*.  Recyclable Cu(I)/Melanin dots for cycloadditions, bioconjugation and cell labeling. Chem. Sci., 2016, 7, 5888-5892.

  7. Yao Sun, Xiaowei Ma,  Zhe Zhang, Ziyan Sun,  Mathias Loft,  Bingbing Ding, Changhao Liu,  Liying Xu,  Meng Yang,  Yuxin Jiang,  Jianfeng, Liu,  Yuling Xiao,  ZhenCheng*, Xuechuan Hong*, A preclinical study on GRPR-targeted 68Ga probes for PET imaging of prostate cancer. Bioconjugate Chem. 2016, 27(8), 1857–1864.

  8. Y. Sun, X. Ma, K. Cheng, B. Wu, J. Duan, H.     Chen, L. Bu, R. Zhang, X. Hu, Z. Deng, L. Xing, X.     Hong*Z. Cheng*. Strained     cycloalkyne as a novel imaging platform for construction of the     multivalent and dual-modal uPAR-targeted imaging probes. Angew.     Chem.Int. Ed. 2015, 54(20), 5981-5984. (HOT     PAPER).

  9. Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian,     Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu, Owen McManus, Min Li, Xuechuan     Hong*, Michael X. Zhu*, Huai Rong Luo*  Identification and optimization     of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4and     TRPC5 channels.British Journal of Pharmacology2015, 172(14),     3495-3509.

  10. Jun Lou,Xiaoyan Yang, Zhigang Rao,Wenwen Qi, Jinhui Li, Haiyu Wang,     Yuxi Li, Jinping Li, Zhiming Wang, Xianming Hu, Peng Liu*, Xuechuan     Hong*. Design and synthesis of     6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase     inhibitors. European Journal of Medicinal Chemistry, 2014,     83, 466-473.

  11. J. Li, J. Lou, Z. Wang, T. Wang, Y. Xiao, P. Liu, X. Hu, X.     Hong*.Design, synthesis and pharmacological evaluation of novel     N-(2-(1,1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl)     sulfonamide derivatives as potential anticonvulsant agents. European     Journal of Medicinal Chemistry, 2015, 92, 370-376.

  12. Jianli Duan, Yao Sun, Hao Chen, Guofu Qiu, Haibing Zhou, Ting Tang,     Zixin Deng, Xuechuan Hong*. Modification of peptides and     proteins via HMDO-mediated ligation in ionic liquids. J.     Org. Chem. 2013, 78(14), 7013–7022.

  13. Hongguang Liu, Shuanglong Liu, Zheng Miao, Han Jiang, Zixin Deng, XuechuanHong*,     Zhen Cheng*. A novel aliphatic18F-labeled probe for PET imaging of     Melanoma. Molecular Pharmaceutics, 2013,10(9),     3384-3391.

  14. Linhui Zhai, Cheng Chang, NingLi, Duc M. Duong, Hao Chen, Zixin     Deng, Jian Yang,  Xuechuan Hong*, Yunping Zhu, Ping Xu*.     Systematic research of the pre-treatment of peptides for quantitative     proteomics using the C18 micro-column, 2013, Proteomics,     13(5), 2229–2237.

  15. Jinmei Zhu,  Chunfeng Wu, Xiaobing Li, Guisheng Wu, Shan Xie,     Qiannan Hu, Zixin Deng, Michael X. Zhu, *Huairong Luo,* Xuechuan Hong*.     Synthesis, biological evaluation and molecular modeling of     substituted2-aminobenzimidazoles as new dual inhibitors of acetylchlinesterase     andbutyrylcholinesterase. Bioorganic& Medicinal Chemistry, 2013,21,     4218.

  16. Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan     Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, ZixinDeng. Metal-free     direct amidation of peptidyl thiol esters with amino acid esters. Green     Chem., 2011, 13, 2723.


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